Journal of Chromatography B, 713 (1998) 61–90

Review

Derivatization procedures for gas chromatographic–mass spectrometric determination of xenobiotics in biological samples, with special attention to drugs of abuse and doping agents a, a b Jordi Segura *, Rosa Ventura , Carmen Jurado a ´ ` Institut Municipal d’ Investigacio Medica IMIM, Drug Research Unit, Av. Dr. Aiguader 80, 08003 Barcelona, Spain b ´ Instituto Nacional de Toxicologıa, P.O. Box 863, 41080 Seville, Spain

Abstract The development of low cost MS detectors in recent years has promoted an important increase in the applicability of GC–MS systems to analyze for the presence of foreign substances in the human body. Drugs and toxic agents are in vivo metabolized in …ver más…

4. Derivatization procedures for GC–MS determination of drugs of abuse....................................................................................... 4.1. Opiates........................................................................................................................................................................... 4.2. Cocaine.......................................................................................................................................................................... 4.3. Cannabis ........................................................................................................................................................................ 4.4. Amphetamines................................................................................................................................................................ 4.5. Benzodiazepines ............................................................................................................................................................. 4.6. LSD............................................................................................................................................................................... 5. Derivatization procedures for GC–MS determination of dope agents........................................................................................... 5.1. Anabolic steroids